Active Ingredient	Stavudine/Lamivudine/Nevirapine
Manufacturer	Cipla
Origin	India
Reference	N/A

What is Triomune (Stavudine/Lamivudine/Nevirapine) used for?

Triomune is a combination therapy for people with Human Immunodeficiency Virus (HIV) infection. It contains three different antiretroviral agents - Stavudine (40mg), Lamivudine (150mg) and Nevirapine (200mg).

Human Immunodeficiency Virus (HIV) attacks specific immune cells called CD4+ cells. If too many of these CD4+ cells are destroyed it can lead to AIDS (acquired immune deficiency syndrome). An enzyme called reverse transcriptase is needed for the virus to continue to replicate and spread. Triomune stops HIV from integrating into the DNA of the infected CD4+ cell. This reduces the amount of HIV and allows the amount of CD4+ to increase.

How should I use Triomune (Stavudine/Lamivudine/Nevirapine) ?

Triomune comes in a packet of 30 tablets. Each tablet contains 40mg of stavudine, 150mg of lamivudine and 200mg of nevirapine. This equates to have the commonly prescribed daily dosage of each treatment. It is recommended to take one tablet twice daily with a glass of water for as long as prewcribed by your doctor.

What are the side effects of Triomune (Stavudine/Lamivudine/Nevirapine) ?

Use of antiretroviral agents like those found in Triomune can occasionally lead to fatal cases of lactic acidosis. Signs yo umay be developing lactic acisosis can include nausea, vomiting and abdominal pain, difficulty breathing, loss of appetite, weight loss, or muscle weakness. Tell your doctor if you notice any of these side effects while taking Triomune.

Other side effects reported with use of the individual active ingredients include:

• Stavudine: severe peripheral neuropathy (usually dose related, and more common in patients with advanced HIV infection or people who have previously experienced peripheral neuropathy
• Lamivudine: nausea, vomiting, headaches, abdominal pain and discomfort, peripheral neuropathy, arthralgias, myalgias, skin rash, pancreatitis
• Nevirapine: development of rash and liver toxicity (these can be potentially life-threatening so should be watched closely)

Please Note

Do not take Triomune if you have ever had an allergic reaction to any of the active ingredients (stavudine / lamivudine / nevirapine).

Triomune must not be taken if you are pregnant or are breastfeeding.

Do not take Triomune if you have kidney or liver disease.

Triomune should only be taken if you have received previous treatment for HIV and specifically treatment with nevirapine.

have previously experienced peripheral neuropathy (damage to nerves in hands and feet causing tingling, numbness and pain)

Some medicines can interact negatively with Triomune. This may result in Triomune not working as intended, or Triomune can have a negative impact on the other medicines. Medicines that should not be taken with Triomune include:

• doxorubicin
• ribavirin
• trimethoprim
• sulfamethoxazole
• rifampin
• other antiretroviral agents (efavirenz, indinavir, lopinavir, nelfinavir, saquinavir, etc)
• ketoconazole
• oral contraceptives
• methadone